Abstract: A two-parameter model for estimating the standard entropy of binary intermetallics was developed based on the analysis of existing thermodynamic data.The model can estimate the standard entropy of binary intermetallics formed by simple metals,involving the multi-systems of Fe,Si,Nb,Ti,Cu,Co,Mg,etc.The standard entropies of 132 intermetallics,such as AlCa,AlCo,CrNi,FeTi,FeSi,FeNb and MoSi,were estimated.It is found that the average error of standard entropy is about 4.86 J·mol^-1·K^-1 and the standard deviation is 6.24 J·mol^-1·K^-1.The accuracy of standard entropy estimated by the two-parameter model is higher than that estimated by the ion binding model.